Developmental genetic effects on externalizing behavior and alcohol use: Examination across two longitudinal samples.

ABSTRACT: Externalizing behavior in early adolescence is associated with alcohol use in adolescence and early adulthood and these behaviors often emerge as part of a developmental sequence. This pattern can be the result of heterotypic continuity, in which different behaviors emerge over time based on an underlying shared etiology. In particular, there is largely a shared genetic etiology underlying externalizing and substance use behaviors. We examined whether polygenic risk for alcohol use disorder predicted (1) externalizing behavior in early adolescence and alcohol use in adolescence in the Early Steps Multisite sample and (2) externalizing behavior in adolescence and alcohol use in early adulthood in the Project Alliance 1 (PAL1) sample. We examined associations separately for African Americans

SUBMITTER: Elam KK 

PROVIDER: S-EPMC9938843 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature