The tight junction protein occludin modulates blood-brain barrier integrity and neurological function after ischemic stroke in mice.

ABSTRACT: Blood-brain barrier (BBB) disruption contributes to brain injury and neurological impairment. Tight junctions (TJs) and cell-cell adhesion complexes develop between endothelial cells in the brain to establish and maintain the BBB. Occludin, the first transmembrane protein identified in TJs, has received intense research interest because numerous in vitro studies have suggested its importance in maintaining BBB integrity. However, its role in maintaining BBB integrity after ischemic stroke is less clear owing to the lack of in vivo evidence. This study aimed to investigate the dynamics and function of occludin across the acute and chronic phases after stroke using occludin-deficient mice. By photochemically induced thrombosis model, the expression of occludin was decreased in brain endothel

SUBMITTER: Sugiyama S 

PROVIDER: S-EPMC9938878 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature