Spatial transcriptomics analysis of zone-dependent hepatic ischemia-reperfusion injury murine model.
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ABSTRACT:
SUBMITTER: Xin J
PROVIDER: S-EPMC9938905 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
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Spatial transcriptomics analysis of zone-dependent hepatic ischemia-reperfusion injury murine model.
Xin Jiaqi J Yang Ting T Wu Xiaoyi X Wu Yingting Y Liu Yi Y Liu Xuan X Jiang Mengxi M Gao Wei W
Communications biology 20230218 1
Hepatic ischemia-reperfusion (I/R) injury is a common complication in liver transplantation. The connection between I/R-induced injury response and liver heterogeneity has yet to be fully understood. In this study, we converge histopathological examination with spatial transcriptomics to dissect I/R injury patterns and their associated molecular changes, which reveal that the pericentral zones are most sensitive to I/R injury in terms of histology, transcriptomic changes, and cell type dynamics. ...[more]
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