Assessing Epstein-Barr virus in gastric cancer: clinicopathological features and prognostic implications.

ABSTRACT:

Background

Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC) was a unique molecular subtype of gastric cancer (GC). However, the clinicopathological characteristics and prognostic role of EBV infection remains unclear. We aimed to evaluate the clinicopathological features of EBVaGC and its role on prognosis.

Methods

EBV-encoded RNA (EBER) in situ hybridization method was used to evaluate the EBV status in GC. The serum tumor markers AFP, CEA, CA19-9 and CA125 of patients were detected before treatment. HER2 expression and microsatellite instability (MSI) status was evaluated according to established criteria. The relationship between EBV infection and clinicopathological factors as well as its role on prognosis were investigated.

Results

420 patients were en

SUBMITTER: Li G 

PROVIDER: S-EPMC9938970 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature