Flow-dependent shear stress affects the biological properties of pericyte-like cells isolated from human dental pulp.

ABSTRACT:

Background

Human dental pulp stem cells represent a mesenchymal stem cell niche localized in the perivascular area of dental pulp and are characterized by low immunogenicity and immunomodulatory/anti-inflammatory properties. Pericytes, mural cells surrounding the endothelium of small vessels, regulate numerous functions including vessel growth, stabilization and permeability. It is well established that pericytes have a tight cross talk with endothelial cells in neoangiogenesis and vessel stabilization, which are regulated by different factors, i.e., microenvironment and flow-dependent shear stress. The aim of this study was to evaluate the effects of a pulsatile unidirectional flow in the presence or not of an inflammatory microenvironment on the biological properties of pericyte-

SUBMITTER: Bertani G 

PROVIDER: S-EPMC9938980 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature