The essential roles of FXR in diet and age influenced metabolic changes and liver disease development: a multi-omics study.

ABSTRACT:

Background

Aging and diet are risks for metabolic diseases. Bile acid receptor farnesoid X receptor (FXR) knockout (KO) mice develop metabolic liver diseases that progress into cancer as they age, which is accelerated by Western diet (WD) intake. The current study uncovers the molecular signatures for diet and age-linked metabolic liver disease development in an FXR-dependent manner.

Methods

Wild-type (WT) and FXR KO male mice, either on a healthy control diet (CD) or a WD, were euthanized at the ages of 5, 10, or 15 months. Hepatic transcriptomics, liver, serum, and urine metabolomics as well as microbiota were profiled.

Results

WD intake facilitated hepatic aging in WT mice. In an FXR-dependent manner, increased inflammation and reduced oxidative phosphorylation wer

SUBMITTER: Yang G 

PROVIDER: S-EPMC9938992 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature