The clinical implications of pre-liver transplant diabetes on post-liver transplant outcomes in patients with NASH: analysis of the UNOS database.

ABSTRACT:

Background and aims

The presence of perioperative diabetes may lead to increased mortality risks following liver transplant (LT) in patients with non-alcoholic steatohepatitis (NASH). This risk factor was evaluated using a UNOS-STAR national database.

Methods

The UNOS-STAR liver transplant registry 2005-2019 was used to select patients with NASH (including cryptogenic liver disease). The following populations were excluded: those younger than 18 years old and those with living donors/dual transplants. Selected patients were stratified into those with and without pre-LT diabetes and compared to the individual mortality endpoints using iterative Cox analyses.

Results

6324 recipients with and 8251 without diabetes were selected. The median follow-up time was 3.07 years.

SUBMITTER: Lee DU 

PROVIDER: S-EPMC9939002 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature