Immune checkpoint inhibitor induced myocarditis, myasthenia gravis, and myositis: A single-center case series.

ABSTRACT:

Background

Immune checkpoint inhibitors can result in overlap syndrome comprised of myasthenia gravis, myositis and myocarditis. However, the mortality predictors have not been clearly delineated.

Methods

We examined the characteristics of 11 patients diagnosed with overlap syndrome at Cleveland Clinic. All the available clinical, diagnostic, biochemical and disease specific factors were examined. Clinical predictors of increased mortality were using student t-test for parametric data and Wilcoxon-signed rank testing for nonparametric data.

Results

Seven patients out of eleven patients were alive during the analysis. Our study did confirm that troponins were indicator of early demise. However, study showed that elevated creatinine, BUN, and decreased hemoglobin were a

SUBMITTER: Longinow J 

PROVIDER: S-EPMC9939107 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature