Association between cannabis use with urological cancers: A population-based cohort study and a mendelian randomization study in the UK biobank.

ABSTRACT:

Background

Legislation of cannabis use has been approved in many European and North American countries. Its impact on urological cancers is unclear. This study was conducted to explore the association between cannabis use and the risk of urological cancers.

Methods

We identified 151,945 individuals with information on cannabis use in the UK Biobank from 2006 to 2010. Crude and age-standardized incidence ratios of different urological cancers were evaluated in the entire cohort and subgroups. Cox regression was performed for survival analysis.

Results

Previous use of cannabis was a significant protective factor for renal cell carcinoma (HR = 0.61, 95%CI:0.40-0.93, p = 0.021) and prostate cancer (HR = 0.82, 95%CI:0.73-0.93, p = 0.002) in multivariable analysis. The asso

SUBMITTER: Huang J 

PROVIDER: S-EPMC9939109 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature