Identification of nine mutant genes and establishment of three prediction models of organ tropism metastases of non-small cell lung cancer.

ABSTRACT:

Background

Most Non-small cell lung cancer (NSCLC) patients tend to have metastases at the initial diagnosis. However, limited knowledge has been established regarding which factors, are associated with its metastases. This study aims to identify more biomarkers associated with its organ tropism metastasis and to establish models for prediction of its metastatic organs.

Methods

We performed targeted next-generation sequencing (NGS) to detect genes related to lung cancer in 272 patients with primary advanced NSCLC from Northeast China. We adopted Fisher test, multivariate logistic regression analysis to identify metastasis-related gene mutations and to establish prediction models.

Results

Mutations of EGFR (p = 0.0003, OR = 2.554) (especially EGFR L858R [p = 0.02, OR =

SUBMITTER: Chen S 

PROVIDER: S-EPMC9939125 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature