Metagenomic analysis of the fecal microbiome in colorectal cancer patients compared to healthy controls as a function of age.

ABSTRACT:

Background and aims

Colorectal cancer (CRC) incidence is increasing in young patients without a clear etiology. Emerging data have implicated the fecal microbiome in CRC carcinogenesis. However, its impact on young onset CRC is poorly defined.

Methods

We performed a meta-analysis of fecal metagenomics sequencing data from n = 692 patients with CRC and n = 602 healthy controls from eleven studies to evaluate features of the fecal metagenome associated with CRC. We hypothesized that known carcinogenic virulence factors (colibactin, fadA) and species abundance may be differentially enriched in young CRC patients relative to older CRC patients and controls.

Results

Summary odds ratios (OR) for CRC were increased with the presence of colibactin (OR 1.92 95% CI 1.08-3.38),

SUBMITTER: Kharofa J 

PROVIDER: S-EPMC9939174 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature