Multiple primary melanoma in association with other personal and familial cancers.

ABSTRACT:

Background

Multiple primary melanoma (MPM) is known to be associated with familial melanoma. However, the association between MPM and other personal and familial cancers is not well documented. The objective of this study was to evaluate the association between MPM and personal history of other cancers or cancer history among first-degree relatives (FDRs).

Methods

We performed a retrospective case-control study including cases with gender-matched MPM and single primary melanoma (SPM) at a 1:2 ratio from the University of Pittsburgh Cancer Institute Melanoma Center Biological Sample and Nevus Bank. The associations between MPM and other cancers were evaluated using univariable and multivariable logistic regression models.

Results

In total, 378 patients (44.2% men; medi

SUBMITTER: Yang X 

PROVIDER: S-EPMC9939182 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature