Impairment of kidney function and kidney cancer: A bidirectional Mendelian randomization study.

ABSTRACT:

Background

Many observational epidemiology studies discovered that kidney cancer and impaired kidney function have a bidirectional relationship. However, it remains unclear whether these two kinds of traits are causally linked. In this study, we aimed to investigate the bidirectional causal relation between kidney cancer and kidney function biomarkers (creatinine-based estimated glomerular filtration rate (eGFRcrea), cystatin C-based estimated glomerular filtration rate (eGFRcys), blood urea nitrogen (BUN), serum urate, and urinary albumin-to-creatinine ratio (UACR)).

Methods

For both directions, single-nucleotide polymorphisms (SNPs), as genetic instruments, for the five kidney function traits were selected from up to 1,004,040 individuals, and SNPs for kidney cancer were f

SUBMITTER: Lin Y 

PROVIDER: S-EPMC9939186 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature