Clinical spectrum of rectal cancer identifies hallmarks of early-onset patients and next-generation treatment strategies.

ABSTRACT:

Background

The incidence of colorectal cancer is increasing among young adults and more rectal cancers are reported. This study aimed to identify the clinical features specific for early-onset rectal cancer and provide insights on cancer management.

Methods

Early-onset (<50 years) and late-onset (≥50 years) rectal cancer patients from a referral tertiary care center (SYSU cohort) and Surveillance Epidemiology and End Results database (SEER cohort) were included to perform a comprehensive comparison on clinical information.

Results

A total of 552 and 80,341 patients with stages I-III rectal cancer were included in the SYSU and SEER cohorts, respectively. In the SYSU cohort, early-onset diseases had significantly higher prevalence of family history of cancer and history

SUBMITTER: Shen D 

PROVIDER: S-EPMC9939204 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature