Impact of comprehensive family history and genetic analysis in the multidisciplinary pancreatic tumor clinic setting.

ABSTRACT:

Background

Genetic testing is recommended for all pancreatic ductal adenocarcinoma (PDAC) patients. Prior research demonstrates that multidisciplinary pancreatic cancer clinics (MDPCs) improve treatment- and survival-related outcomes for PDAC patients. However, limited information exists regarding the utility of integrated genetics in the MDPC setting. We hypothesized that incorporating genetics in an MDPC serving both PDAC patients and high-risk individuals (HRI) could: (1) improve compliance with guideline-based genetic testing for PDAC patients, and (2) optimize HRI identification and PDAC surveillance participation to improve early detection and survival.

Methods

Demographics, genetic testing results, and pedigrees were reviewed for PDAC patients and HRI at one instituti

SUBMITTER: Everett JN 

PROVIDER: S-EPMC9939217 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature