N⁶ -methyladenosine RNA demethylase FTO regulates extracellular matrix-related genes and promotes pancreatic cancer cell migration and invasion.

ABSTRACT: Pancreatic cancer (PC) is a deadly disease, and its post-transcriptional gene regulation mechanism remains unclear. The abundant extracellular matrix (ECM) in PC plays an important role in tumor progression. This study is the first to focus on the role of N⁶ -methyladenosine (m⁶ A) RNA methylation, an emerging post-transcriptional regulatory mechanism, in the regulation of the ECM in PC. Here, we found that ADAMTS2, COL12A1, and THBS2 were associated with the prognosis of PC by comprehensive analysis of differentially expressed genes from two independent GEO expression profile datasets and m⁶ A-related genes in RMVar database (PAAD). GO and KEGG enrichment analysis found that these m⁶ A-related targets are chiefly functionally concentrated in the

SUBMITTER: Wang W 

PROVIDER: S-EPMC9939218 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature