Influence of the skeletal muscle index on pharmacokinetics and toxicity of fluorouracil.

ABSTRACT:

Background

The body composition of patients has been associated with tolerability and effectiveness of anticancer therapy. This study aimed to assess the influence of the skeletal muscle index (SMI) on the pharmacokinetics and toxicity of fluorouracil.

Methods

Patients treated in an oncological practice with fluorouracil-based chemotherapy and undergoing therapeutic drug monitoring were retrospectively investigated. Computed tomography images were analyzed to measure abdominal skeletal muscle areas in Hounsfield units for the psoas major muscle, back and total skeletal muscle to determine the SMI. For the latter, an automated segmentation method was used additionally. SMI measures were tested as covariates on fluorouracil clearance in a population pharmacokinetic model. Furt

SUBMITTER: Schmulenson E 

PROVIDER: S-EPMC9939223 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature