Comparison of the long-term outcomes of patients with hepatocellular carcinoma within the Milan criteria treated by ablation, resection, or transplantation.

ABSTRACT:

Background

Liver transplantation (LT), resection (LR), and ablation (LA) are three curative-intent treatment options for patients with early hepatocellular carcinoma (HCC). We aimed to develop a prognostic calculator to compare the long-term outcomes following each of these therapies.

Methods

A total of 976 patients with HCC within the Milan criteria who underwent LT, LR, and LA between 2009 and 2019 from four institutions were evaluated. Multistate competing risks prediction models for recurrence-free survival (RFS), recurrence within the Milan criteria (RWM), and HCC-specific survival (HSS) were derived to develop a prognostic calculator.

Results

During a median follow-up of 51 months, 420 (43%) patients developed recurrence. In the multivariate analysis, larger tum

SUBMITTER: Zhang NN 

PROVIDER: S-EPMC9939228 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature