Progestogens exhibit progestogen-, promoter- and isoform-specific effects via the progesterone receptor.

ABSTRACT: Hormonal contraceptives (HCs) and hormone replacement therapy (HRT) are therapies designed to target the progesterone receptor (PR) to prevent unwanted pregnancy and to alleviate the symptoms of menopause, respectively, in women. Although these therapies are widely used globally, few studies have investigated in parallel how the transcriptional responses of the progestogens used in these therapies compare to each other via the PR isoforms (PR-A and PR-B). Using dose-response promoter-reporter and endogenous gene expression assays, we compared the transcriptional responses of six widely-used progestogens via each PR isoform. The present study shows that progestogens exhibit progestogen-specific potencies and efficacies via both PR isoforms. In addition, the endogenous gene expression data r

SUBMITTER: Enfield K 

PROVIDER: S-EPMC9939308 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature