Sialic acid-mediated photochemotherapy enhances infiltration of CD8⁺ T cells from tumor-draining lymph nodes into tumors of immunosenescent mice.

ABSTRACT: Immunoscenescence plays a key role in the initiation and development of tumors. Furthermore, immunoscenescence also impacts drug delivery and cancer therapeutic efficacy. To reduce the impact of immunosenescence on anti-tumor therapy, this experimental plan aimed to use neutrophils with tumor tropism properties to deliver sialic acid (SA)-modified liposomes into the tumor, kill tumor cells via SA-mediated photochemotherapy, enhance infiltration of neutrophils into the tumor, induce immunogenic death of tumor cells with chemotherapy, enhance infiltration of CD8⁺ T cells into the tumor-draining lymph nodes and tumors of immunosenescent mice, and achieve SA-mediated photochemotherapy. We found that CD8⁺ T cell and neutrophil levels in 16-month-old mice were signif

SUBMITTER: Sui D 

PROVIDER: S-EPMC9939359 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature