A porcine islet-encapsulation device that enables long-term discordant xenotransplantation in immunocompetent diabetic mice.

ABSTRACT: Islet transplantation is an effective treatment for type 1 diabetes (T1D). However, a shortage of donors and the need for immunosuppressants are major issues. The ideal solution is to develop a source of insulin-secreting cells and an immunoprotective method. No bioartificial pancreas (BAP) devices currently meet all of the functions of long-term glycemic control, islet survival, immunoprotection, discordant xenotransplantation feasibility, and biocompatibility. We developed a device in which porcine islets were encapsulated in a highly stable and permeable hydrogel and a biocompatible immunoisolation membrane. Discordant xenotransplantation of the device into diabetic mice improved glycemic control for more than 200 days. Glycemic control was also improved in new diabetic mice "relay-tran

SUBMITTER: Ajima K 

PROVIDER: S-EPMC9939365 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature