Differential cell composition and split epidermal differentiation in human palm, sole, and hip skin.

ABSTRACT: Palmoplantar skin is structurally and functionally unique, but the transcriptional programs driving this specialization are unclear. Here, we use bulk and single-cell RNA sequencing of human palm, sole, and hip skin to describe the distinguishing characteristics of palmoplantar and non-palmoplantar skin while also uncovering differences between palmar and plantar sites. Our approach reveals an altered immune environment in palmoplantar skin, with downregulation of diverse immunological processes and decreased immune cell populations. Further, we identify specific fibroblast populations that appear to orchestrate key differences in cell-cell communication in palm, sole, and hip. Dedicated keratinocyte analysis highlights major differences in basal cell fraction among the three sites and dem

SUBMITTER: Wiedemann J 

PROVIDER: S-EPMC9939370 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature