Quantitative comparison of protein-protein interaction interface using physicochemical feature-based descriptors of surface patches.

ABSTRACT: Driving mechanisms of many biological functions in a cell include physical interactions of proteins. As protein-protein interactions (PPIs) are also important in disease development, protein-protein interactions are highlighted in the pharmaceutical industry as possible therapeutic targets in recent years. To understand the variety of protein-protein interactions in a proteome, it is essential to establish a method that can identify similarity and dissimilarity between protein-protein interactions for inferring the binding of similar molecules, including drugs and other proteins. In this study, we developed a novel method, protein-protein interaction-Surfer, which compares and quantifies similarity of local surface regions of protein-protein interactions. protein-protein interaction-Surfer

SUBMITTER: Shin WH 

PROVIDER: S-EPMC9939524 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature