Coffee Intake, Caffeine Metabolism Genotype, and Survival Among Men with Prostate Cancer.

ABSTRACT:

Background

Coffee intake may lower prostate cancer risk and progression, but postdiagnosis outcomes by caffeine metabolism genotype are not well characterized.

Objective

To evaluate associations between coffee intake, caffeine metabolism genotype, and survival in a large, multicenter study of men with prostate cancer.

Design, setting, and participants

Data from The PRACTICAL Consortium database for 5727 men with prostate cancer from seven US, Australian, and European studies were included. The cases included had data available for the CYP1A2 -163C>A rs762551 single-nucleotide variant associated with caffeine metabolism, coffee intake, and >6 mo of follow-up.

Outcome measurements and statistical analysis

Multivariable-adjusted Cox proportional hazards models acr

SUBMITTER: Gregg JR 

PROVIDER: S-EPMC9939555 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature