Prediction of COPD acute exacerbation in response to air pollution using exosomal circRNA profile and Machine learning.

ABSTRACT: Ambient fine particulate matter (PM_2.5) is linked to an increased risk of chronic obstructive pulmonary disease (COPD) exacerbations, which significantly increase the risk of mortality in COPD patients. Identifying the subtype of COPD patients who are sensitive to environmental aggressions is necessary. Using in vitro and in vivo PM_2.5 exposure models, we demonstrate that exosomal hsa_circ_0005045 is upregulated by PM_2.5 and binds to the protein cargo peroxiredoxin2, which functionally aggravates hallmarks of COPD by recruiting neutrophil elastase and triggering in situ release of tumor necrosis factor (TNF)-α by inflammatory cells. The biological function of hsa_circ_0005045 associated with aggravation of COPD is validated using exosome-transplantation and

SUBMITTER: Meng Q 

PROVIDER: S-EPMC9939562 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature