Mathematical model of mechanobiology of acute and repeated synaptic injury and systemic biomarker kinetics.

ABSTRACT:

Background

Blast induced Traumatic Brain Injury (bTBI) has become a signature casualty of military operations. Recently, military medics observed neurocognitive deficits in servicemen exposed to repeated low level blast (LLB) waves during military heavy weapons training. In spite of significant clinical and preclinical TBI research, current understanding of injury mechanisms and short- and long-term outcomes is limited. Mathematical models of bTBI biomechanics and mechanobiology of sensitive neuro-structures such as synapses may help in better understanding of injury mechanisms and in the development of improved diagnostics and neuroprotective strategies.

Methods and results

In this work, we formulated a model of a single synaptic structure integrating the dynamics of the sy

SUBMITTER: Gharahi H 

PROVIDER: S-EPMC9939777 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature