Preparing for the Next Influenza Season: Monitoring the Emergence and Spread of Antiviral Resistance.

ABSTRACT:

Purpose

The relaxation of pandemic restrictions in 2022 has led to a reemergence of respiratory virus circulation worldwide and anticipation of substantial influenza waves for the 2022/2023 Northern Hemisphere winter. Therefore, the antiviral susceptibility profiles of human influenza viruses circulating in Germany were characterized.

Methods

Between October 2019 (week 40/2019) and March 2022 (week 12/2022), nasal swabs from untreated patients with acute respiratory symptoms were collected in the national German influenza surveillance system. A total of 598 influenza viruses were isolated and analyzed for susceptibility to oseltamivir, zanamivir and peramivir, using a neuraminidase (NA) inhibition assay. In addition, next-generation sequencing was applied to assess molecular

SUBMITTER: Oh DY 

PROVIDER: S-EPMC9939793 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature