Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-cholesterol Levels in J-MICC Study Participants.

ABSTRACT:

Background

Environmental and genetic factors are suggested to exhibit factor-based association with HDL-cholesterol (HDL-C) levels. However, the population-based effects of environmental and genetic factors have not been compared clearly. We conducted a cross-sectional study using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study to evaluate the population-based impact of smoking, drinking, and genetic factors on low HDL-C.

Methods

Data from 11,498 men and women aged 35-69 years were collected for a genome-wide association study (GWAS). Sixty-five HDL-C-related SNPs with genome-wide significance (P < 5 × 10^-8) were selected from the GWAS catalog, of which seven representative SNPs were defined, and the population-based impact was estimate

SUBMITTER: Nindita Y 

PROVIDER: S-EPMC9939920 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature