Urine Galectin-3 binding protein reflects nephritis activity in systemic lupus erythematosus.

ABSTRACT:

Background

Lupus nephritis (LN) is a major and severe organ involvement in systemic lupus erythematosus (SLE), whose diagnosis and treatment necessitate to perform kidney biopsy, which is an invasive procedure. Non-invasive urine biomarkers are an active area of investigation to support LN diagnosis and management.

Objective

To investigate the role of urinary galectin-3 binding protein (u-Gal-3BP) as a candidate biomarker of renal disease in biopsy proven LN.

Patients and methods

Levels of u-Gal-3BP were investigated in a cross-sectional fashion by ELISA in 270 subjects: 86 LN patients, 63 active SLE patients with no kidney involvement, 73 SLE patients with inactive disease and 48 age and sex-matched population-based controls (PBC). Moreover, urine samples were analys

SUBMITTER: Faustini F 

PROVIDER: S-EPMC9939930 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature