Nano-bio interaction between human immunoglobulin G and nontoxic, near-infrared emitting water-borne silicon quantum dot micelles.

ABSTRACT: In recent years, the field of nanomaterials has exponentially expanded with versatile biological applications. However, one of the roadblocks to their clinical translation is the critical knowledge gap about how the nanomaterials interact with the biological microenvironment (nano-bio interactions). When nanomaterials are used as drug carriers or contrast agents for biological imaging, the nano-bio interaction-mediated protein conformational changes and misfolding could lead to disease-related molecular alterations and/or cell death. Here, we studied the conformation changes of human immunoglobulin G (IgG) upon interaction with silicon quantum dots functionalized with 1-decene, Pluronic-F127 (SiQD-De/F127 micelles) using UV-visible, fluorescence steady state and excited state kinetics, cir

SUBMITTER: Chinnathambi S 

PROVIDER: S-EPMC9939978 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature