Early post-induction augmented therapy improves outcome in children and adolescents with T-cell acute lymphoblastic leukemia.

ABSTRACT:

Introduction

T-cell acute lymphoblastic leukemia (T-ALL) accounts for approximately 15% of all newly diagnosed ALL in children and adolescents and is associated with worse outcomes compared to pre-B ALL. We aimed to decrease T-ALL relapses by intensifying our regimen.

Methods

Patients with T-ALL were treated using two different regimens; before September 2014, patients were treated per St. Jude Total XV protocol; subsequently, a major change was adopted by adding two intensive blocks: FLAG and Reintensification. Cranial radiation was limited to patients with WBC ≥ 100 k/μl at diagnosis and/or patients with CNS2/CNS3 status.

Results

Between June 2005 and April 2020, a total of 100 patients (76 males) were treated and followed up for a median of 70 months (range 14-181)

SUBMITTER: Abu Shanap M 

PROVIDER: S-EPMC9940001 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature