The impact of obesity and endocrine therapy on the prognosis of premenopausal women with hormone receptor-positive breast cancer: A single-institute retrospective study.

ABSTRACT:

Background

Higher body mass index (BMI) is associated with worse prognosis in pre- and postmenopausal patients with breast cancer (BC). However, there is insufficient evidence regarding the optimal adjuvant endocrine therapy for obese premenopausal women with hormone receptor (HR)-positive BC.

Aim

To evaluate the impact of obesity and adjuvant endocrine therapy on prognosis in premenopausal patients with BC.

Methods and results

We retrospectively reviewed the medical record of premenopausal women who received curative surgery for clinical stage I-III HR-positive BC from 2007 to 2017. Patients were classified into five groups according to BMI: underweight (UW), normal weight (NW), obese 1 degree (OB1), obese 2 degree (OB2), and obese 3 degree (OB3) categories. The prim

SUBMITTER: Ozaki Y 

PROVIDER: S-EPMC9940008 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature