Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations.

ABSTRACT: Adult white adipose tissue (WAT) harbors distinct mesenchymal stromal cell subpopulations that differentially affect WAT function and plasticity. Here we unveil the cellular landscape of the perinatal epididymal WAT primordium using single-cell transcriptomics in male mice. We reveal that adipocyte precursor cells and fibro-inflammatory progenitors (FIPs) emerge as functionally distinct PDGFRβ⁺ subpopulations within the epididymal WAT anlagen prior to adipocyte accrual. We further identify important molecular and functional differences between perinatal and adult FIPs, including differences in their pro-inflammatory response, adipogenic capacity and anti-adipogenic behavior. Notably, we find that transient overexpression of Pparg in PDGFRβ⁺ cells only during postnatal

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC9940036 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature