Reliable Cognitive Decline in Late-Life Major Depression.

ABSTRACT:

Objective

Major depression in older adults increases the statistical likelihood of dementia. It is challenging to translate statistical evidence of cognitive decline at the group level into knowledge of individual cognitive outcomes. The objective of the current study is to investigate 2-year reliable cognitive change in late-life depression (LLD), which will enhance understanding of cognitive changes in LLD and provide a means to assess individual change.

Methods

In a sample of non-depressed cognitively normal older adults or NDCN (n = 113), we used linear regression to predict tests of global cognition, processing speed-executive functioning, and memory administered 1 and 2 years later. Stepwise regression was used to select covariates among demographics and raw test score

SUBMITTER: Manning KJ 

PROVIDER: S-EPMC9940117 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature