Treatment selection in multi-arm multi-stage designs: With application to a postpartum haemorrhage trial.

ABSTRACT:

Background

Multi-arm multi-stage trials are an efficient, adaptive approach for testing many treatments simultaneously within one protocol. In settings where numbers of patients available to be entered into trials and resources might be limited, such as primary postpartum haemorrhage, it may be necessary to select a pre-specified subset of arms at interim stages even if they are all showing some promise against the control arm. This will put a limit on the maximum number of patients required and reduce the associated costs. Motivated by the World Health Organization Refractory HaEmorrhage Devices trial in postpartum haemorrhage, we explored the properties of such a selection design in a randomised phase III setting and compared it with other alternatives. The objectives are: (1) to

SUBMITTER: Choodari-Oskooei B 

PROVIDER: S-EPMC9940121 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature