Autologous conditioned serum for chronic pain in patients with osteoarthritis: A feasibility observational study.

ABSTRACT:

Background

Autologous conditioned serum is a product of blood origin, with fragmented evidence of therapeutic properties in osteoarthritis chronic pain. This pilot observational prospective study aimed to evaluate the feasibility of a treatment with conditional autologous serum (ACS) in patients with severe chronic pain and grade I-III osteoarthritis and to describe its cytokine content.

Methods

We prospectively collected data on consecutive patients affected by osteoarthritis grade I to III and treated with four weekly injections of ACS at our outpatient pain service. The primary outcome was pain intensity, measured with the visual analogic scale (VAS). Additional outcomes were symptoms evaluated using joint district-specific scales. The study also evaluated concentrations

SUBMITTER: Ippolito M 

PROVIDER: S-EPMC9940252 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature