'Chemistry at the speed of sound': automated 1536-well nanoscale synthesis of 16 scaffolds in parallel.

ABSTRACT: Screening of large and diverse libraries is the 'bread and butter' in the first phase of the discovery of novel drugs. However, maintenance and periodic renewal of high-quality large compound collections pose considerable logistic, environmental and monetary problems. Here, we exercise an alternative, the 'on-the-fly' synthesis of large and diverse libraries on a nanoscale in a highly automated fashion. For the first time, we show the feasibility of the synthesis of a large library based on 16 different chemistries in parallel on several 384-well plates using the acoustic dispensing ejection (ADE) technology platform. In contrast to combinatorial chemistry, we produced 16 scaffolds at the same time and in a sparse matrix fashion, and each compound was produced by a random combination of di

SUBMITTER: Gao L 

PROVIDER: S-EPMC9940305 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature