Interleukin 17 B regulates colonic myeloid cell infiltration in a mouse model of DSS-induced colitis.

ABSTRACT: Cytokines play vital roles in the pathogenesis of inflammatory bowel disease. IL17B is protective in the development of colitis. However, how IL17B regulates intestinal inflammation and what cells are regulated by IL17B is still unknown. Here, we aimed to illustrate the IL17B dependent cellular and molecular changes in colon tissue in a mouse colitis model. The results showed that IL17B expression in colon tissues was elevated in inflamed tissues than non-inflamed tissues of IBD patients. Wild type (WT) and Il17b deficient (Il17b ^-/-) mice were given 2.5% dextran sodium sulfate (DSS) water, and in some case, Il17b ^-/- mice were treated with recombinant mouse IL17B. IL17B deficiency resulted in severe DSS-induced colitis with exaggerated weight los

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9940313 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature