Single-cell RNA sequencing reveals the immune microenvironment and signaling networks in cystitis glandularis.

ABSTRACT:

Introduction

Cystitis glandularis (CG) is a rare chronic bladder hyperplastic disease that mainly manifests by recurrent frequent urination, dysuria and gross hematuria. The current lack of unified diagnosis and treatment criteria makes it essential to comprehensively describe the inflammatory immune environment in CG research.

Methods

Here, we performed scRNA-sequencing in CG patients for the first time, in which four inflamed tissues as well as three surrounding normal bladder mucosa tissues were included. Specifically, we isolated 18,869 cells to conduct bioinformatic analysis and performed immunofluorescence experiments.

Results

Our genetic results demonstrate that CG does not have the classic chromosomal variation observed in bladder tumors, reveal the specific e

SUBMITTER: Zhou TL 

PROVIDER: S-EPMC9940314 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature