Sex-specific associations between diabetes and dementia: the role of age at onset of disease, insulin use and complications.

ABSTRACT:

Background

Whether the association of type 2 diabetes (T2DM) with dementia was differed by sex remains unclear, and the roles of age at onset of disease, insulin use and diabetes' complications in their association are unknown.

Methods

This study analyzed data of 447 931 participants from the UK Biobank. We used Cox proportional hazards models to estimate sex-specific hazard ratios (HRs) and 95% confidence intervals (CI), and women-to-men ratio of HRs (RHR) for the association between T2DM and incident dementia [all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VD)]. The roles of age at onset of disease, insulin use and diabetes' complications in their association were also analyzed.

Results

Compared to people with no diabetes at all, people with T2

SUBMITTER: Zhou C 

PROVIDER: S-EPMC9940390 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature