Amyloid-β accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism.

ABSTRACT:

Background

Astrocytes play a central role in maintaining brain energy metabolism, but are also tightly connected to the pathogenesis of Alzheimer's disease (AD). Our previous studies demonstrate that inflammatory astrocytes accumulate large amounts of aggregated amyloid-beta (Aβ). However, in which way these Aβ deposits influence their energy production remain unclear.

Methods

The aim of the present study was to investigate how Aβ pathology in astrocytes affects their mitochondria functionality and overall energy metabolism. For this purpose, human induced pluripotent cell (hiPSC)-derived astrocytes were exposed to sonicated Aβ₄₂ fibrils for 7 days and analyzed over time using different experimental approaches.

Results

Our results show that to maintain stab

SUBMITTER: Zysk M 

PROVIDER: S-EPMC9940442 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature