Genetic Variants in PHACTR1 & LPL Mediate Restenosis Risk in Coronary Artery Patients.

ABSTRACT:

Background and objective

Coronary artery disease (CAD) is a major cause of death worldwide. Revascularization via stent placement or coronary artery bypass grafting (CABG) are standard treatments for CAD. Despite a high success rate, these approaches are associated with long-term failure due to restenosis. Risk factors associated with restenosis were investigated using a case-control association study design.

Methods

Five thousand two hundred and forty-two patients were enrolled in this study and were assigned as follows: Stenosis Group: 3570 patients with CAD >50% without a prior stent or CABG (1394 genotyped), and Restenosis Group: 1672 patients with CAD >50% and prior stent deployment or CABG (705 genotyped). Binomial regression models were applied to investigate the asso

SUBMITTER: Al Hageh C 

PROVIDER: S-EPMC9940491 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature