Surface-Functionalized Metal-Organic Frameworks for Binding Coronavirus Proteins.

ABSTRACT: Since the outbreak of SARS-CoV-2, a multitude of strategies have been explored for the means of protection and shielding against virus particles: filtration equipment (PPE) has been widely used in daily life. In this work, we explore another approach in the form of deactivating coronavirus particles through selective binding onto the surface of metal-organic frameworks (MOFs) to further the fight against the transmission of respiratory viruses. MOFs are attractive materials in this regard, as their rich pore and surface chemistry can easily be modified on demand. The surfaces of three MOFs, UiO-66(Zr), UiO-66-NH₂(Zr), and UiO-66-NO₂(Zr), have been functionalized with repurposed antiviral agents, namely, folic acid, nystatin, and tenofovir, to enable specific interacti

SUBMITTER: Desai AV 

PROVIDER: S-EPMC9940617 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature