The Cancer Surfaceome Atlas integrates genomic, functional and drug response data to identify actionable targets.

ABSTRACT: Cell-surface proteins (SPs) are a rich source of immune and targeted therapies. By systematically integrating single-cell and bulk genomics, functional studies and target actionability, in the present study we comprehensively identify and annotate genes encoding SPs (GESPs) pan-cancer. We characterize GESP expression patterns, recurrent genomic alterations, essentiality, receptor-ligand interactions and therapeutic potential. We also find that mRNA expression of GESPs is cancer-type specific and positively correlates with protein expression, and that certain GESP subgroups function as common or specific essential genes for tumor cell growth. We also predict receptor-ligand interactions substantially deregulated in cancer and, using systems biology approaches, we identify cancer-specific GE

SUBMITTER: Hu Z 

PROVIDER: S-EPMC9940627 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature