β-carotene improves fecal dysbiosis and intestinal dysfunctions in a mouse model of vitamin A deficiency.

ABSTRACT: Vitamin A deficiency (VAD) results in intestinal inflammation, increased redox stress and reactive oxygen species (ROS) levels, imbalanced inflammatory and immunomodulatory cytokines, compromised barrier function, and perturbations of the gut microbiome. To combat VAD dietary interventions with β-carotene, the most abundant precursor of vitamin A, are recommended. However, the impact of β-carotene on intestinal health during VAD has not been fully clarified, especially regarding the VAD-associated intestinal dysbiosis. Here we addressed this question by using Lrat^-/-Rbp^-/- (vitamin A deficient) mice deprived of dietary preformed vitamin A and supplemented with β-carotene as the sole source of the vitamin, alongside with WT (vitamin A sufficient) mice. We found that di

SUBMITTER: Honarbakhsh M 

PROVIDER: S-EPMC9940628 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature