Systemic enhancement of antitumour immunity by peritumourally implanted immunomodulatory macroporous scaffolds.

ABSTRACT: A tumour microenvironment abundant in regulatory T (T_reg) cells aids solid tumours to evade clearance by effector T cells. Systemic strategies to suppress T_reg cells or to augment immunity can elicit autoimmune side effects, cytokine storms and other toxicities. Here we report the design, fabrication and therapeutic performance of a biodegradable macroporous scaffold, implanted peritumourally, that releases a small-molecule inhibitor of transforming growth factor β to suppress T_reg cells, chemokines to attract effector T cells and antibodies to stimulate them. In two mouse models of aggressive tumours, the implant boosted the recruitment and activation of effector T cells into the tumour and depleted it of T_reg cells, which resulted in an 'immuno

SUBMITTER: Majedi FS 

PROVIDER: S-EPMC9940651 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature