Development of a platform for broadband, spectra-fitted, tissue optical phantoms.

ABSTRACT:

Significance

Current methods of producing optical phantoms are incapable of accurately capturing the wavelength-dependent properties of tissue critical for many optical modalities.

Aim

We aim to introduce a method of producing solid, inorganic phantoms whose wavelength-dependent optical properties can be matched to those of tissue over the wavelength range of 370 to 950 nm.

Approach

The concentration-dependent optical properties of 20 pigments were characterized and used to determine combinations that result in optimal fits compared to the target properties over the full spectrum. Phantoms matching the optical properties of muscle and nerve, the diffuse reflectance of pale and melanistic skin, and the chromophore concentrations of a computational skin model with varyi

SUBMITTER: Walter AB 

PROVIDER: S-EPMC9940728 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature