Radiochemical Quality Control Methods for Radium-223 and Thorium-227 Radiotherapies.

ABSTRACT: Background: The majority of radiopharmaceuticals for use in disease detection and targeted treatment undergo a single radioactive transition (decay) to reach a stable ground state. Complex emitters, which produce a series of daughter radionuclides, are emerging as novel radiopharmaceuticals. The need for validation of chemical and radiopurity with such agents using common quality control instrumentation is an area of active investigation. Here, we demonstrate novel methods to characterize ²²⁷Th and ²²³Ra. Materials and Methods: A radio-TLC scanner and a γ-counter, two common and widely accessible technologies, as well as a solid-state α-particle spectral imaging camera were evaluated for their ability to characterize and distinguish ²²

SUBMITTER: Hasson A 

PROVIDER: S-EPMC9940811 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature