Understanding Hippocampal Development in Young Children With Autism Spectrum Disorder.

ABSTRACT:

Objective

We examined growth trajectories of hippocampal volume (HV) in early childhood in a longitudinal cohort of male and female participants with autism spectrum disorder (ASD) and typically developing (TD) individuals, and investigated HV in those with large brains. Relations between factors potentially associated with hippocampal size and growth were investigated.

Method

Participants received 1 to 3 structural magnetic resonance imaging scans between ages 25 and 80 months (unique participants: ASD, n =200; TD, n =110; total longitudinal scans, n = 593). HV growth during this period was examined using mixed-effects linear models. Associations between early HV and growth rates, and IQ and adaptive functioning, were evaluated.

Results

After accounting for cerebral

SUBMITTER: Reinhardt VP 

PROVIDER: S-EPMC9940822 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature