Deciphering the Molecular Mechanism of Yifei-Sanjie Pill in Cancer-Related Fatigue.

ABSTRACT:

Background

The incidence of cancer-related fatigue (CRF) is increasing, but its lack of clear pathogenesis makes its prevention and treatment difficult. Therefore, it is of great significance to clarify the pathogenesis of CRF and find effective methods to treat it.

Methods

The CRF model was established by intraperitoneal injection of LLC cells in ICR mice to explore the pathogenesis of CRF and verify the therapeutic effect of the Yifei-Sanjie pill (YFSJ). The active components of YFSJ were found by LC/MS, the in vitro inflammatory infiltration model of skeletal muscle was constructed by TNF-α and C2C12 myoblasts, and the results of in vivo experiments were verified by this model.

Results

Behavioral analysis results showed that YFSJ alleviated CRF; histological

SUBMITTER: Wu Y 

PROVIDER: S-EPMC9940949 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature